Name: Haowen Zhang
Academic Title: Professor
Email: hwzhang@suda.edu.cn
Address: Medical Building 402-2308, North District of Dushu Lake Campus
Contact Phone: +86 512 65880065
Ⅰ、Educational and Professional Experience
1、Educational Background：
2009.09-2014.06 School of Radiation Medicine and Protection, Soochow University, PhD in Medicine (Doctoral Supervisor: Prof. Fenju Liu)
2004.09-2009.06 School of Radiation Medicine and Public Health, Soochow University, Bachelor of Medicine
2、Professional Experience：
2023.07- Present School of Radiation Medicine and Protection, Soochow University, Professor
2017.07-2023.06 School of Radiation Medicine and Protection, Soochow University, Associate Professor
2016.07-2020.06 Institute of Radiation Medicine, Fudan University, Postdoc (Postdoctoral Co-Advisor: Prof. Chunlin Shao)
2014.08-2017.06 School of Radiation Medicine and Protection, Soochow University, Lecturer
Ⅱ、Research Focus
1、Frontiers in Radiobiology: Biological mechanisms of ultra-high dose rate irradiation
2、Frontiers in Radiotherapy: FLASH radiotherapy & Tumor immunotherapy
3、Frontiers in Radiation Medicine: Cutting-edge radiation injury management
Ⅲ、Project/Honor/Award
1、Nuclear Technology R&D Project (2024), State Administration of Science. Technology and Industry for National Defense, under the 14th Five-Year Plan, Research on key technologies of proton FLASH and its combination with immunotherapy, HJSYF2024(05), ￥1,100,000 Role: P.I. of Subproject, 2025.01-2027.12。
2、Sichuan Provincial Key S&T Special Projects (2024),Development of ultrahigh-dose-rate X-ray FLASH radiotherapy equipment, 2024ZDZX0027, ￥550,000. Role: P.I. fromPartner Institution, 2024.11-2027.10。
3、NSFC-Key Program, Optimal physical parameters and biological mechanisms of FLASH photon radiotherapy combined with tumor immunotherapy, 12235004, ￥1,164,000. Role: P.I. fromPartner Institution, 2023.01-2027.12。
4、Collaborative Research Project of the State Key Laboratory of Radiation Medicine and Protection (2023), Mechanisms of FLASH photon irradiation in regulating the spatiotemporal radio-susceptibility of genomic DNA, GZN1202303, ￥750,000, 2023.06- 2026.05。Role: P.I.
5、NSFC-General Program, Mechanism of intestinal radiation damage mediated by FLASH photon exposure, 82173455, ￥550,000, 2022.01-2025.12。Role: P.I.
Ⅳ、Academic Part-time Roles & Student Guidance Outcomes
1、Member of Scientific Committee, FLASH Radiotherapy & Particle Therapy (FRPT) (2024-Present)
2、Young Editorial Board Member of the 7th Editorial Committee, International Journal of Radiation Medicine and Nuclear Medicine (2024-Present)
3、Member of the Academic Committee, Sichuan Clinical Medical Center for Radiation and Therapy (2023-Present)
4、Member of the Academic Committee, Sichuan-Chongqing Joint Laboratory for Advanced Radiation Technology and Medical Engineering Applications (2025-Present)
5、First Prize, National Excellent Science Popularization Micro-Video Competition, Ministry of Science and Technology of the People's Republic of China (Sole Advisor) (2021)
Ⅴ、Recent Five-Year Representative Research Outcomes
1、Xiaolin Shi#, Yiwei Yang#, Wei Zhang#, et al., FLASH X-ray spares intestinal crypts from pyroptosis initiated by cGAS-STING activation upon radio-immunotherapy. PNAS. 2022, 119(43): e2208506119. (Corresponding author)
2、Xiaolin Shi#, Wei Zhang#, Cheng Gu#, et al., NAD+ depletion radiosensitizes 2-DG-treated glioma cells by abolishing metabolic adaptation. Free Radical Biology and Medicine. 2021, 162: 514-522. (Corresponding author)
3、Songling Hu#, Lin Zhu#, Yimeng Song#, et al., Radiation-induced abscopal reproductive effect is driven by TNF-α/p38 MAPK/Rac1 axis in Sertoli cells. Theranostics. 2021, 11(12): 5742-5758. (Corresponding author)
4、Fei Chen#, Yushuo Zhang#, Songling Hu, et al., TIGAR/AP-1 axis accelerates the division of Lgr5− reserve intestinal stem cells to reestablish intestinal architecture after lethal radiation. Cell Death and Disease. 2020, 11(7): 501. (Corresponding author)
5、Xinrui Zhao#, Songling Hu#, Liang Zeng, et al., Irradiation combined with PD-L1-/- and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation. iScience. 2022, 25: 104690. (Corresponding author)