Name: Hongying Yang
Academic Title: Professor
Email: yanghongying@suda.edu.cn
Address: Medical Building 402-2306, North District of Dushu Lake Campus
Contact Phone: +86 512 65882637
Ⅰ、Educational and Professional Experience
1、Educational Background：
1996.9-1999.7 Ph.D. Institute of Biophysics, Chinese Academy of Sciences
1993.9-1996.4 M.Eng. Harbin Engineering University
1989.9-1993.7 B.Sc. University of Electronic Science and Technology of China
2、Professional Experience：
2011.8- Present School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Professor
2007.6-2011.7 Department of Radiation Oncology, Massachusetts General Hospital/Harvard Medical School, Instructor/Research Scientist
2001.9-2007.5 Department of Radiation Oncology, Massachusetts General Hospital/Harvard Medical School, Postdoc Research Fellow
1999.7-2001.7 Institute of Biophysics, Chinese Academy of Sciences, Assistant Professor
Ⅱ、Research Focus
1、The dual roles of Reprimo (RPRM) in tumor radiosensitization and normal tissue radioprotection: mechanisms and implications
2、The mechanisms and implications of radiation-induced bystander effect
Ⅲ、Project/Honor/Award
1、NSFC, The mechanism by which RPRM lactylation reduces tumor radiosensitivity and radiation-induced abscopal effects via promoting DNA damage repair, 32571425, ￥500,000, 2026.01-2029.12。Role: P. I.
2、NSFC, The regulatory effect of RPRM on radiation-induced bystander signals and the underlying mechanisms, 32271279, ￥540,000, 2023.01-2026.12。Role: P. I.
Ⅳ、Academic Part-time Roles & Student Guidance Outcomes
1、Member of the Committee of Cancer Radiotherapy Protection, China Anti-Cancer Association, 2019-present
2、Member of the Radiotoxicology Committee, Jiangsu Society of Toxicology, 2017-2024
3、Member of the Academic Committee of the Fujian Provincial University Key Laboratory of Radiation Biology, 2015-present
4、Editorial Board Member of Scientific Reports, 2017-present
5、Mentor to three “Jun Zheng Scholars” (2012, 2013, 2019) and supervisor for multiple “Medical School Student Extracurricular Research Projects”(2018, 2020, 2021)
Ⅴ、Recent Five-Year Representative Research Outcomes
1、Shi W, Wang J, Li Z, Xu S, Wang J, *Zhang L, *Yang H. Reprimo (RPRM) mediates neuronal ferroptosis via CREB-Nrf2/SCD1 pathways in radiation-induced brain injury. Free Radic Biol Med. 2024, 213:343-358.
2、Ye Z, Wang J, Shi W, Zhou Z, Zhang Y, Wang J, *Yang H. Reprimo (RPRM) as a potential preventive and therapeutic target for radiation-induced brain injury via multiple mechanisms. Int J Mol Sci. 2023, 24(23): 17055.
3、Yarui Zhang, Guomin Ou, Zhou Zhou, Jingdong Wang, *Hongying Yang. Protocol for IPO11 deletion and re-expression in H460 lung cancer cells using CRISPR-Cas9 and plasmid transfection. STAR Protoc. 2023, 4(2):102317.
4、 Yarui Zhang, Guomin Ou, Zhujing Ye, Zhou Zhou, Qianlin Cao, Mengting Li, Jingdong Wang, Jianping Cao, *Hongying Yang. RPRM negatively regulates ATM levels through its nuclear translocation on irradiation mediated by CDK4/6 and IPO11. iScience. 2022, 25(10):105115.
5、Zixuan Li, Zhou Zhou, Shuaiyu Tian, Kailu Zhang, Gangli An, Yarui Zhang, Renyuxue Ma, Binjie Sheng, Tian Wang, *Hongying Yang, *Lin Yang. RPRM deletion preserves hematopoietic regeneration by promoting EGFR-dependent DNA repair and hematopoietic stem cell proliferation post ionizing radiation. Cell Biol Int. 2022, 46(12):2158-2172.
6、Linlin Ma, Zhujing Ye, Yarui Zhang, Wenyu Shi, Jingdong Wang, *Hongying Yang, Irradiated microvascular endothelial cells may induce bystander effects in neural stem cells leading to neurogenesis inhibition, J Radiat Res, 2022, 63(2):192-201.
7、Yang X, Ma L, Ye Z, Shi W, Zhang L, *Wang J, *Yang H. Radiation-induced bystander effects may contribute to radiation-induced cognitive impairment. Int J Radiat Biol. 2021, 97(3):329-340.
8、Shi W, Liu W, Ma J, Lu J, Yang X, Wang J, Cao J, Tian Y, *Yang H, *Zhang L. The role of Atg7-mediated autophagy in ionizing radiation-induced neural stem cell damage. Gene. 2020, 738(2020):144485
Note: * Corresponding author.