Name: Yang Jiao
Academic Title: Professor, Doctoral Supervisor
Position: Vice Director of Center for Radiation Biology
Email: jiaoyang@suda.edu.cn
Address: Medical Building 402-2305, North District of Dushu Lake Campus
Contact Phone: +86 512 65880052
Ⅰ、Educational and Professional Experience
1、Educational Background
2004.9-2007.6 PhD in Toxicology, Soochow University, China
2001.9-2004.6 Master of Microbiology, Soochow University, China
1996.9-2001.6 MD in Clinical Medicine, Southeast University, China
2、Professional Experience
2018.7-Present Professor, School of Radiation Medicine and Protection, Soochow University
2010.9-2018.6 Associate Professor, School of Radiation Medicine and Protection, Soochow University
2007.8-2010.8 Tutor, School of Radiation Medicine and Protection, Soochow University
2015.4-2016.3 Research Scholar, Department of Pathology, Oklahoma University, USA
2005.4-2007.1 Research Fellow, Department of Oncology, Georgetown University, USA
Ⅱ、Research Focus
1、Molecular mechanisms of radiation-induced pulmonary injury
2、Development of novel therapeutic strategies for radiation-induced diseases
3、Molecular mechanisms of lipid metabolic reprogramming in regulating radiosensitivity of tumor microenvironment
Ⅲ、Project/Honor/Award
1、National Natural Science Foundation of China General Project, Intercellular Activation of UBC9-Mediated SUMOylation by Rac1 Promotes Radiation-Induced Pulmonary Fibrosis: Mechanisms and Interventional Strategies, 82574020, ¥470,000, 2026.01-2029.12, Principal Investigator.
2、Internal collaborative project of the Radiation Medicine Collaborative Innovation Center, Basic Research on the Application of Targeted Rac1-Based Precision Radiation Immunotherapy for Liver Cancer, FY202401, ¥500,000, 2025.04-2027.03, Principal Investigator.
3、Open Project of the National Health Commission Key Laboratory of Nuclear Medicine Technology Translation, Strategic Research on Precision Intervention of Radiation-Induced Lung Injury Targeting the Deubiquitination Regulatory Pathway, 2023HYX005, ¥500,000, 2024.01-2026.12, Principal Investigator.
4、Innovation Project of the National Key Laboratory of Radiation Medicine and Protection (Co-built by the Province and Ministry), Construction and Validation of a Multi-Dimensional Low-Dose Radiation Dose-Effect Relationship Model, GZC00402，¥500,000，2022.11-2023.10，Principal Investigator.
5、Ministry of Science and Technology National Key Research and Development Program, Key Technology Research and System Establishment for High-Fluence Radiation Therapy (HFRT) in the Treatment of Digestive System Malignant Tumors (Liver, Pancreatic, and Colorectal Cancer), 2022YFC2503700, 2022.11-2025.12, ¥14.85 million, Participated.
Ⅳ、Academic Part-time Roles & Student Guidance Outcomes
• Member of the Radiation Medicine and Protection Branch of the Chinese Medical Association
• Member of the Radiation Toxicology Branch of the Chinese Toxicology Society
• Member of the Standing Committee, Radiation Medicine Professional Committee of the Jiangsu Provincial Research-oriented Hospitals Association
• Mentorship to two doctoral students and twelve master's degree students.
Ⅴ、Recent Five-Year Representative Research Outcomes
1、Yang Jiao#, Jiawei Ren#, Shichang Xie#, Nan Yuan, Jiaqi Shen, Huafang Yin, Jian Wang, Hongjuan Guo, Jianping Cao, Xin Wang, Depei Wu*, Zhemin Zhou*, Xiaofei Qi*. Raffinose-metabolizing bacteria impair radiation-associated hematopoietic recovery via the bile acid/FXR/NF-κB signaling pathway, Gut Microbes, 2025, 17(1): 2488105.
2、Yang Feng, Lirong Zhang, Youbin Zhang, Ying Xu, Kaixiao Zhou, Zhao Yang, Wei Zhu, Qi Zhang, Jianping Cao, Lili Wang*, Yang Jiao*. NEDD4-Mediated Endothelial-Mesenchymal Transition Participates in Radiation-Induced Lung Injury Through the ATM Signaling Pathway, Dose Response, 2025, 23(2):15593258251352726.
3、Yiting Tang, Tingya Wang, Liming Gu, Ying Xu, Zhao Yang, Wei Zhu, Qi Zhang, Judong Luo, Jianping Cao*, Yang Jiao*. USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling, Int. J. of Radiation Oncology · Biology · Physics, 2024, 119(4):1261-1274. doi.org/10.1016/j.ijrobp.2024.01.220
4、YiDi Wang, Dong Kong, Han Gao, ChuanSheng Du, HuiYuan Xue, Kun Liu, XiangHui Kong, WenYue Zhang, YuChen Yin, Tao Wu, Yang Jiao*, Liang Sun*. Multiple Mesh-type Real Human Cell Models for Dosimetric Application Coupled with Monte Carlo Simulations, Radiat Res, 2023, 200(2):176-187.
5、Yang Feng, Ping Yuan, Hongjuan Guo, Liming Gu, Zhao Yang, Jian Wang, Wei Zhu, Qi Zhang, Jianping Cao, Lili Wang*, Yang Jiao*. METTL3 Mediates Epithelial-Mesenchymal Transition by Modulating FOXO1 mRNA N6 -Methyladenosine-Dependent YTHDF2 Binding: A Novel Mechanism of Radiation-Induced Lung Injury, Adv Sci (Weinh),2023, 10(17):e2204784.
6、Rongrong Wang#, Depei Wu#, Jianfeng Dai#, Jiaqi Shen, Jianjie Rong, Zixing Chen, Yang Jiao*, Xiaofei Qi*. USP11 plays a critical role in the onset and progression of acute graft-versus-host disease：Novel target for precision therapeutics, Pharmacological Research, 2023,189:106707.
7、Hengzhao Zhuang#, Bo Yu#, Dan Tao#, Xiaoyan Xu, Yijun Xu, Jian Wang*, Yang Jiao*, Lili Wang*. The role of m6A methylation in therapy resistance in cancer, Molecular Cancer, 2023,22:91.
8、Yang Jiao, Jing Xu, Bin Song, Ailing Wu, Lu Pan, Ying Xu, Fenghao Geng, Xiaoqian Li, Congzhao Zhao, Min Hong, Xuanyu Meng, Judong Luo, Pengfei Liu, Ming Li, Wei Zhu, Jianping Cao*, Shuyu Zhang*. Interferon regulatory factor 1-triggered free ubiquitin protects the intestines against radiation-induced injury via CXCR4/FGF2 signaling, MedComm, 2022, 3:e168.
9、Yiting Tang#, Qian Yuan#, Congzhao Zhao, Ying Xu, Qi Zhang, Lili Wang, Zhiqiang Sun, Jianping Cao, Judong Luo*, Yang Jiao*. Targeting USP11 may alleviate radiation-induced pulmonary fibrosis by regulating endothelium tight junction, International Journal of Radiation Research, 2022,98(1):30-40.
10、Lihuan Wang, Congzhao Zhao, Haoru Shan, Yang Jiao*, Qi Zhang, Xiaoran Li*, Jianyong Yu, and Bin Ding*. Deoxycholic acid-modified microporous SiO2 nanofibers mimicking colorectal microenvironment to optimize radiotherapy-chemotherapy combined therapy, Biomedical Materials, 16 (2021) 065020.