Name: Youhang Li
Academic Title: Postdoctoral Research Scientist
Email: yhli666@suda.edu.cn
Address: Medical Building 402-2303, North District of Dushu Lake Campus
Contact Phone: 0512-65882451
Ⅰ、Educational and Professional Experience
1、Educational Background：
2018.09-2025.06 Capital Normal University & Scripps Research (USA), Joint Training Program, Ph.D. Thesis topic: Molecular mechanisms of tumorigenesis
2014.09-2018.06 Qingdao University, School of Basic Medicine, Bachelor of Science
2、Professional Experience：
2025.07-Present Soochow University, School of Radiation Medicine and Protection, Postdoctoral Researcher
Ⅱ、Research Focus
1、Mechanisms of Synergy Between Radiotherapy and Immunotherapy in Cancer Treatment
2、The Role of Replication Fork Stability in Tumorigenesis
3、Effects of Microgravity on Genomic Stability and DNA Repair Mechanisms in Cells
Ⅲ、Project/Honor/Award
1、Awarded the National Scholarship for Doctoral Students from the Ministry of Education/Ministry of Finance (2024.10; 30,000 Yuan)
Ⅳ、Recent Five-Year Representative Research Outcomes
1. Youhang Li, Zhang, Y., Shah, S.B., Chang, C.Y., Wang, H., and Wu, X. (2024). MutSbeta protects common fragile sites by facilitating homology-directed repair at DNA double-strand breaks with secondary structures. Nucleic Acids Res 52, 1120-1135. 10.1093/nar/gkad1112.
2. Zhang H#, Youhang Li#, Shah S#, Li S, Li Q, Oaks J, Lv T, Shi L, Wang H, Wang D, and Wu X (2025). ATM priming and end resection-coupled phosphorylation of MRE11 is important for fork protection and replication restart, Proc. Natl. Acad. Sci (USA) 10.1073/pnas.2422720122.
3. Shah, S.B#.,Youhang Li#, Li, S., Hu, Q., Wu, T., Shi, Y., Nguyen, T., Ive, I., Shi, L., Wang, H., and Wu, X. (2024). 53BP1 deficiency leads to hyperrecombination using break-induced replication (BIR). Nature Commun. 15, 8648. 10.1038/s41467-024-52916-z.