王广林，副教授、硕士生导师

电话：0512-65880052     传真：0512-65884380

电子邮箱：glwang@suda.edu.cn

通讯地址：苏州工业园区仁爱路199号,邮编215123

个人简历：

2017.07-至今，苏州大学放射医学与防护学院，分子影像与核医学研究中心，副教授；

2015.06-2017.07，苏州大学放射医学与防护学院，分子影像与核医学研究中心，讲师；

2014.07-2015.05，中国科学院核能安全技术研究所；

2009.11-2014.07，荷兰代尔夫特理工大学，反应堆研究所Prof H. Th. Wolterbeek课题组；

2006.09-2009.06，中国科学技术大学国家同步辐射实验室李良彬教授课题组；

2005.07-2006.08，佳通轮胎（中国）研发中心;

2001.09-2005.06,安徽大学高分子材料与工程专业。

研究方向：

1.放射性核素标记方法的研究

2.放射性核素标记用于药物药代动力学研究

3.放射性标记药物在肿瘤诊断和治疗中的应用研究


科研项目：

  1. 国家自然科学基金面上项目，2020-2023，66万，项目负责人。

  2. 江苏省自然科学基金优秀青年，2020.07-2023.06，50万，项目负责人。

  3. 中国博士后特别资助，2018.06-2019.12，15万，项目负责人。

  4. 国家自然科学基金国际合作项目，2018.01-2022.12，40万，合作单位负责人。

  5. 国家自然科学青年基金，2017.01-2019.12，20万，项目负责人。

  6. 国家重点研发计划-数字诊疗装备研发，2016.01-2018.12，25万，课题负责人。

  7. 江苏省自然科学青年基金， 2016.07-2019.07，20万，项目负责人。


代表性论著：

  1. Dual Functional Radioactive Gel-Microspheres for Combinatorial Radioembolization and Photothermal Therapy of Hepatocellular Carcinoma，J. Sun, X. Sun, L. Yin, S. Jin, Q. Huang, Yi Dong, X. Gu, Y. Zhang,* Y. Jin,* R. Zhu, andG. Wang*,Adv. Healthcare Mater., 2025, 2401057.

  2. 99mTc/90Y radiolabeled biodegradable gel microspheres for lung shutting fraction assessment and radioembolization in hepatocellular carcinoma theranostics. Y. Dong, L. Yin, J. Huang, D. Hu, J. Sun, Z. Zhang, Z. Li, B. Zhong*, R. Zhu*,G. Wang*,Materials Today Bio, 2024, 29, 101367.

  3. PSMA and Sigma-1 receptor dual-targeted peptide mediates superior radionuclide imaging and therapy of prostate cancer, Z. Huangfu, J. Yang, J. Sun, B. Xu, L. Tao, J. Wu, F. Wang*,G. Wang*, F. Meng, Z, Zhong*.J. Control. Release, 2024, 375, 767-775

  4. Ultrastable PLGA-Coated 177Lu-Microspheres for Radioembolization Therapy of Hepatocellular Carcinoma, S. Jin, J. Huang, Y. Dong, D. Hu, J. Sun, Z. Li, B.-Y. Zhong*, Z. Liu*, R. Zhu, andG. Wang*.Mol. Pharmaceutics, 2024, 31, 3407-3415.

  5. Radionuclide-labeled Microspheres for Radio-immunotherapy of Hepatocellular Carcinoma. S. Yang, C. Mu, T. Liu, P. Pei, W. Shen, Y. Zhang,G. Wang,* L. Chen,* and K. Yang*,Adv. Healthcare Mater. 2023, 2300944

  6. Rational Design of Mesoporous Coordination Polymer Nanophotosensitizers for Photodynamic Tumor Ablation，H. Li#, H. Xu#,G. Wang#, J. Chen#, D. Ji, Y. Huang, G. Cui, H. He,* and Z. Guo*,ACS Appl. Mater. Interfaces2023, 15, 21746−21753

  7. Polydopamine-Coated Radiolabeled Microspheres for Combinatorial Radioembolization and Photothermal Cancer Therapy, M. Wu, L. Zhang, K. Shi, D. Zhao, W. Yong, L. Yin, R. Huang,G. Wang,* G. Huang, and M. Gao*,ACS Appl. Mater. Interfaces2023, 15, 12669−12677.

  8. Imaging-Guided Targeted Radionuclide Tumor Therapy: From Concept to Clinical Translation, J. Sun, Z. Huangfu, J. Yang,G. Wang*, K. Hu*, M. Gao, Z. Zhong*.Adv. Drug Deliver. Rev., 2022, 190, 114538.

  9. Acidity-Activated Charge Conversion of 177Lu-Labeled Nanoagent for the Enhanced Photodynamic Radionuclide Therapy of Cancer. Y. Zhang#,G. Wang#, Q. Li*, Y. Jiang, W. Chen, M. Zhao, G. Liang, Q. Miao*.ACS Appl. Mater. Interfaces 2022, 14, 3, 3875–3884.

  10. Facile Preparation of 177Lu-microspheres for Hepatocellular Carcinoma Radioisotope Therapy. M. Wu, K. Shi, R. Huang, C. Liu, L. Yin, W. Yong, J. Sun,G. Wang*, and M. Gao*.Chinese Chem. Lett.,2022, 33, 3492-3496.

  11. Redox-sensitive iodinated polymersomes carrying histone deacetylase inhibitor as a dual-functional nano-radiosensitizer for enhanced radiotherapy of breast cancer，Z. Zhu, M. Wu, J. Sun, Z. Huangfu, L. Yin, W. Yong, J. Sun,G. Wang*, F. Meng, Z. Zhong*,Drug Delivery, 2021, 28, 2301-2309.

  12. X. Zhang, M. Zhao, L. Wen, M. Wu, Y. Yang, Y. Zhang, Y. Wu, J. Zhong*, H. Shi, J. Zeng,G. Wang* and M. Gao*, Sequential SPECT and NIR-II imaging of tumor and sentinel lymph node metastasis for diagnosis and image-guided surgery.Biomater. Sci., 2021, 9, 3069.

  13. J. Cao, Y. Wei, Y. Zhang,G. Wang*, X. Ji, and Z. Zhong*, Iodine-rich Polymersomes Enable Versatile SPECT/CT Imaging and Potent Radioisotope Therapy for Tumor In Vivo,ACS Appl. Mater. Interfaces, 2019, 11, 18953-18959.

  14. G. Wang, R. M. de Kruijff, D. Abou, N. Ramos, E. Mendes, L. E. Franken, H. T. Wolterbeek and A. G. Denkova*, Pharmacokinetics of Polymersomes Composed of Poly(butadiene-ethylene oxide); Healthy vs. Tumor Bearing Mice,J. Biomed. Nano. 2016, 12, 320-328.

  15. G. Wang, A. Hoornweg, H Th. Wolterbeek, L. Franken, E. Mendes, and A. G. Denkova*, Enhanced Retention of Encapsulated Ions in Cross-Linked Polymersomes，J. Phys. Chem. B, 2015, 119, 4300–4308.

  16. G. Wang, R.M. de Kruijff, A. Rol, L. Thijssen, E. Mendes, A. Morgenstern, F. Bruchertseifer, M. C. A. Stuart, H. Th. Wolterbeek and A.G. Denkova*, Retention Studies of Recoiling Daughter Nuclides of 225Ac in Polymer Vesicles,Appl. Radiat. Isotopes, 2014, 45-53, 85.

  17. G. Wang, R. de Kruijff, M. C. A. Stuart, E. Mendes, H. T. Wolterbeek and A. G. Denkova*.  Polymersomes as Radionuclide Carriers Loaded via Active Ion Transport through the Hydrophobic Bilayer,Soft Matter, 2013, 9, 727.


荣誉奖励:

1、10th Targeted alpha radionuclide therapy meeting travel award, 2017.

2、苏州市高层次紧缺人才，2017。

3、8th Targeted alpha radionuclide therapy meeting travel award, 2013.

4、Best poster award in Begium Biofuture 2011.

课程教学

1、《实验核医学》（本科生课程）

2、《核药学》（本科生课程）

3、《专业英语》（研究生课程）

招生信息：

本课题组热忱欢迎有志从事科研工作的本科/硕士研究生以及博士后到课题组学习工作。招收化学、药学或放射性药物相关专业背景的硕士研究生和博士后。