赵利,教授、博士生导师

电子邮箱:lizhao@suda.edu.cn
通讯地址:苏州工业园区仁爱路199, 邮编215123

 

个人简历:

赵利现任苏州大学放射医学与防护学院教授,博士生导师。20009月至20046武汉工程大学本科,获高分子材料与工程专业学士学位;20049月至20096华南理工大学硕博联读,获材料学专业博士学位;20098月至20158月先后在日本滋贺医科大学和京都大学从事博士后研究;20159月加入苏州大学,被聘为副教授;20247月晋升为教授。

 

研究方向:

1中子俘获治疗及相关药物开发

2、纳米生物材料的制备及应用

 

科研项目:

1、国家自然科学基金面上项目,富含硼-10纳米氮化硼介导的脑胶质瘤靶向硼中子俘获治疗及其机制研究,2024.12027.12,主持

2、国家自然科学基金青年项目,基于表面功能化碳纳米角的靶向纳米药物的构建和化疗光热联合肿瘤治疗研究,2017.12019.12,主持

3、江苏省自然科学基金青年项目,基于表面功能化碳纳米角的肿瘤靶向纳米药物研究,2016.72019.6,主持

4、放射医学与辐射防护国家重点实验室创新项目,肿瘤靶向SPECT可视化纳米硼药的制备及其在硼中子俘获治疗中的应用研究,2021.12022.12,主持

5苏州市医疗卫生科技创新--应用基础研究,兼具肿瘤靶向和近红外荧光成像的BNCT纳米硼药研制与临床应用研究,2021.72024.6,主持

6、硼泰医疗器械有限公司横向项目,Pengtera系列新型BNCT硼药研发,2023.122026.12,主持

7中核集团横向项目,新型纳米硼递送剂的研发及其对脑胶质瘤的靶向放疗研究,2024.22026.12,主持

8、苏州大学附属第二医院横向项目,BNCT肿瘤靶向硼药的研究现状及其临床转化前景调查研究,2023.42024.3,主持

 

代表性论著:

1Y. Zhang, H.G. Kang, H.-Z. Xu, H. Luo, M. Suzuki, Q. Lan*, X. Chen*, N. Komatsu*, L. Zhao*, Tumor Eradication by Boron Neutron Capture Therapy with 10B‐enriched Hexagonal Boron Nitride Nanoparticles Grafted with Poly (glycerol), Advanced Materials, 2023, 35(35), 2301479.

2C. Wang, Y.-H. Xu, H.-Z. Xu, K. Li, Q. Zhang, L. Shi, L. Zhao*, X. Chen*, PD-L1 blockade TAM-dependently potentiates mild photothermal therapy against triple-negative breast cancer, Journal of Nanobiotechnology, 2023, 21(1), 476.

3H.-Z. Xu, T.-F. Li, Y. Ma, K. Li, Q. Zhang, Y.-H. Xu, Y.-C. Zhang, L. Zhao*, X. Chen*, Targeted photodynamic therapy of glioblastoma mediated by platelets with photo-controlled release property, Biomaterials 2022, 290, 121833.

4H.-Z. Xu, T.-F. Li, C. Wang, Y. Ma, Y. Liu, M.-Y. Zheng, Z.-J.-Y. Liu, J.-B. Chen, K. Li, S.-K. Sun, N. Komatsu, Y.-H. Xu, L. Zhao*, X. Chen*, Synergy of nanodiamond-doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells, Journal of Nanobiotechnology, 2021, 19(1), 268.

5D. Li, Y. Zhang, J. Xu, F. Yoshino, H. Xu, X. Chen, L. Zhao*, Surface-engineered carbon nanohorns as a theranostic nanodevice for photoacoustic imaging and effective radiochemotherapy of cancer, Carbon, 2021, 180, 185-196.

6Z. Chen, S.-J. Yuan, K. Li, Q. Zhang, T.-F. Li, H.-C. An, H.-Z. Xu, Y. Yue, M. Han, Y.-H. Xu, N. Komatsu, L. Zhao*, X. Chen*, Doxorubicin-polyglycerol-nanodiamond conjugates disrupt STAT3/IL-6-mediated reciprocal activation loop between glioblastoma cells and astrocytes, Journal of Controlled Release, 2020, 320, 469-483.

7F. Yoshino, T. Amano, Y. Zou, J. Xu, F. Kimura, Y. Furusho, T. Chano, T. Murakami, L. Zhao*, N. Komatsu*, Preferential Tumor Accumulation of Polyglycerol Functionalized Nanodiamond Conjugated with Cyanine Dye Leading to Near-Infrared Fluorescence In Vivo Tumor Imaging, Small, 2019, 15(48), 1901930.

8X. Yi, M. Xu, H. Zhou, S. Xiong, R. Qian, Z. Chai, L. Zhao*, K. Yang*, Ultrasmall Hyperbranched Semiconducting Polymer Nanoparticles with Different Radioisotopes Labeling for Cancer Theranostics, ACS Nano, 2018, 12(9), 9142-9151.

9T.-F. Li, K. Li, Q. Zhang, C. Wang, Y. Yue, Z. Chen, S.-J. Yuan, X. Liu, Y. Wen, M. Han, N. Komatsu, Y.-H. Xu, L. Zhao*, X. Chen*, Dendritic cell-mediated delivery of doxorubicin-polyglycerol-nanodiamond composites elicits enhanced anti-cancer immune response in glioblastoma, Biomaterials, 2018, 181, 35-52.

10T.-F. Li, K. Li, C. Wang, X. Liu, Y. Wen, Y.-H. Xu, Q. Zhang, Q.-Y. Zhao, M. Shao, Y.-Z. Li, M. Han, N. Komatsu, L. Zhao*, X. Chen*, Harnessing the cross-talk between tumor cells and tumor-associated macrophages with a nano-drug for modulation of glioblastoma immune microenvironment, Journal of Controlled Release, 2017, 268, 128-146.

11L. Zhao, Y.-H. Xu, H. Qin, S. Abe, T. Akasaka, T. Chano, F. Watari, T. Kimura, N. Komatsu*, X. Chen*, Platinum on Nanodiamond: A Promising Prodrug Conjugated with Stealth Polyglycerol, Targeting Peptide and Acid-Responsive Antitumor Drug, Advanced Functional Materials, 2014, 24(34), 5348-5357.

12L. Zhao, Y.-H. Xu, T. Akasaka, S. Abe, N. Komatsu, F. Watari, X. Chen*, Polyglycerol-coated nanodiamond as a macrophage-evading platform for selective drug delivery in cancer cells, Biomaterials, 2014, 35(20), 5393-5406.

13L. Zhao, T. Chano, S. Morikawa, Y. Saito, A. Shiino, S. Shimizu, T. Maeda, T. Irie, S. Aonuma, H. Okabe, T. Kimura, T. Inubushi, N. Komatsu*, Hyperbranched Polyglycerol-Grafted Superparamagnetic Iron Oxide Nanoparticles: Synthesis, Characterization, Functionalization, Size Separation, Magnetic Properties, and Biological Applications, Advanced Functional Materials, 2012, 22(24), 5107-5117.

14L. Zhao, T. Takimoto, M. Ito, N. Kitagawa, T. Kimura, N. Komatsu*, Chromatographic Separation of Highly Soluble Diamond Nanoparticles Prepared by Polyglycerol Grafting, Angewandte Chemie-International Edition, 2011, 50(6), 1388-1392.

 

专利

1、一种可分散碳纳米角/金颗粒纳米复合物及其制备和应用,赵利,李道昌,中国发明专利,ZL202110444469.4

 

荣誉奖励:

1、湖北省科技进步二等奖,靶向肿瘤相关巨噬细胞介导肺癌免疫治疗的药物研发及临床应用,2023.02,排名7/10

2Waka-ayu prize, The 30th University Symposium,日本滋贺医科大学,2014.03排名1/1

 

课程教学招生信息

物理化学、有机化学、无机及分析化学实验(本科生课程)

 

招生信息

专业:放射医学(博士生)、生物医学工程(硕士生)